Abstract #3386
Pulse Sequence Optimization for Improved MRF Scan Efficiency
Jesse Ian Hamilton 1 , Katherine L Wright 1 , Yun Jiang 1 , Luis Hernandez-Garcia 2 , Dan Ma 1 , Mark Griswold 1,3 , and Nicole Seiberlich 1,3
1
Biomedical Engineering, Case Western Reserve
University, Cleveland, OH, United States,
2
Biomedical
Engineering, University of Michigan, Ann Arbor, MI,
United States,
3
Radiology,
Case Western Reserve University, Cleveland, OH, United
States
A flexible framework for MR Fingerprinting pulse
sequence design is presented that includes the MRI
signal encoding, gridding, and pattern recognition
directly in the optimization. The method was validated
in a phantom study by designing sequence for mapping T1,
T2, and M0 in under 3s using a highly undersampled
spiral trajectory. Parameter maps obtained with the
optimized sequence have fewer artifacts and higher
agreement with spin echo measurements compared to
unoptimized sequences. The optimization framework is
easily generalizable to other MRF applications.
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