Abstract #3379
Modulation and regulation of intracellular pH in healthy human brain studied by means of Chemical Exchange Saturation Transfer (CEST) at 7T
Vitaliy Khlebnikov 1 , Alex Bhogal 1 , Jeroen Siero 1 , Michel Italiaander 2 , Vincent Boer 1 , Peter Luijten 1 , Hans Hoogduin 1 , and Dennis Klomp 1
1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands,
2
MR
Coils BV, Drunen, Netherlands
pH homeostasis is vital to normal cellular physiology.
31P Magnetic Resonance Spectroscopy (31P MRS) is
currently a gold standard for the non-invasive
measurements of intracellular pH (pHi) using inorganic
phosphate (Pi) as a probe. Low resolution and low pH
sensitivity are major limitation of 31P-based pH
measurements. The aim of this work is to show that
emerging APT (Amide Proton Transfer) imaging is superior
to 31P MRS in terms of both resolution and pH
sensitivity by getting an estimate on buffering capacity
of different brain compartments in healthy human brain
at 7T.
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