Abstract #3376
Chemical exchange saturation transfer (CEST) MR imaging of rat liver with fasting or CCl4 intoxication
Shuzhong Chen 1 , Min Deng 1 , Jing Yuan 2 , and Yi-Xiang Wang 1
1
Department of Imaging and Interventional
Radiology, The Chinese University of Hong Kong, Shatin,
N.T., Hong Kong,
2
Medical
Physics and Research Department, Hong Kong Sanatorium &
Hospital, Happy Valley, Hong Kong
CEST MR is a promising molecular imaging technique which
enables indirect detection of metabolites with
exchangeable protons or molecules. Both APT and
glycoCEST value decrease after CCl4 48 hours injection
and 24 hours fasting. However, compared with APT,
glycoCEST shows high intra- and inter-subject standard
deviation in both experiments. This may due to the rapid
exchange rate of glycogen hydroxyl protons and their
proximity to the water resonance. The observed change in
APT reflected the alteration of amide proton levels by
injecting CCl4 and fasting. The reliability of glycoCEST
in vivo liver at 3T should be further investigated.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
