Abstract #3282
Reproducibility and Sensitivity of T 2 * Measured in Patients with Squamous Cell Carcinoma of the Head and Neck at 3T
Rafal Panek 1 , Liam Welsh 1 , Maria A. Schmidt 1 , Alex Dunlop 1 , Kate L. Newbold 1 , Kee Wong 1 , Angela M. Riddell 1 , Dow-Mu Koh 1 , Dualta Mcquaid 1 , Shreerang A. Bhide 1 , Kevin J. Harrington 2 , Christopher M. Nutting 2 , Georgina Hopkinson 3 , Cheryl Richardson 3 , Simon P. Robinson 4 , and Martin O. Leach 1
1
Royal Marsden NHS FT and Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
2
Royal
Marsden NHS FT and Institute of Cancer Research, London,
United Kingdom,
3
Royal
Marsden NHS FT, London, United Kingdom,
4
Institute
of Cancer Research, Sutton, Surrey, United Kingdom
In this study, the reproducibility of T2* was
calculated, and blood oxygen saturation dependence of
tissue relaxation times simulated, for patients with
squamous cell carcinoma of the head and neck at 3T. The
simulation of tissue T2* shows that the sensitivity of
the method increases as a function of blood oxygenation,
and is sufficient for the majority of SCCHN oxygen
tensions, with the exception of anoxic and severely
hypoxic tumour regions where sensitivity is lower than
reproducibility coefficient (11%). Both baseline T2*
values and blood volumes should be taken into account
when employing changes in T2* for assessing tissue
oxygenation.
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