Abstract #3250
Variable Flip Angle T1 Mapping in the Human Brain with Reduced T2 Sensitivity Using Fast RF-Spoiled Gradient Echo Imaging
Rahel Heule 1 , Carl Ganter 2 , and Oliver Bieri 1
1
Division of Radiological Physics, Department
of Radiology, University of Basel Hospital, Basel,
Switzerland,
2
Department
of Radiology, Klinikum rechts der Isar, Technische
Universitt Mnchen, Munich, Germany
Many T
1
mapping
methods have been developed, however, they deliver
substantially varying quantification results for the
same tissues and at equal field strength. The variable
flip angle (VFA) method based on radiofrequency spoiled
gradient echo imaging provides 3D MR data sets and
allows for volumetric T
1
mapping in clinically
feasible times. In this work, a new postprocessing
approach is proposed to overcome the T
2
-related
bias originating from incomplete spoiling in
conventional VFA T
1
quantification.
Excellent agreement with inversion recovery reference
measurements was obtained in vivo for human brain
tissues demonstrating the potential of the new method to
provide accurate whole-brain T
1
quantification
at high-resolution.
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