Abstract #3168
High-Throughput Diffusion-Tensor-Imaging of Mouse Brains using a four-coil system
John C Nouls 1 , Alexandra Badea 1 , Gary P Cofer 1 , and G Allan Johnson 1
1
Center for In Vivo Microscopy, Duke
University Medical Center, Durham, NC, United States
Diffusion-tensor imaging of mouse brains, used in
conjunction with population atlases and statistical
methods, can detect subtle pathologies. The total scan
time can be prohibitive. We present a parallel
acquisition, four-coil system increasing
diffusion-tensor imaging throughput in a small bore, 7T
scanner. The geometry of the coil system and its
shielding has been optimized to preserve SNR, enabling a
decrease in imaging time per specimen of 63%. The
fractional anisotropy measurement bias due to off-center
imaging was 9%. Bringing each coil slightly closer to
the magnet isocenter may further decrease imaging time
towards the maximum 75% reduction achievable.
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