Abstract #3061
Quantifying pulmonary perfusion in health and pulmonary disease with DCE-MRI: effect of bolus delay
J. Tim Marcus 1 , Barry Ruijter 1 , Taco Kind 2 , Rudolf Verdaasdonk 1 , and Anton Vonk Noordegraaf 2
1
Physics & Medical Technology, VU University
Medical Center, Amsterdam, Netherlands,
2
Pulmonology,
VU University Medical Center, Amsterdam, Netherlands
The aim of this study is to explore the effect of the
delay between arterial input function and lung tissue
enhancement curve on the observed pulmonary blood flow.
3D dynamic contrast-enhanced MRI was applied in healthy
control subjects (n=5), and patients with pulmonary
hypertension (n=14) or pulmonary artery atresia (n=5).
Median bolus delay time ranged from 1.5 s for healthy
subjects to 3.0 s for pulmonary hypertension patients.
Not correcting for delay resulted in an average
Pulmonary Blood Flow underestimation of 47 percent.
Thus, correction for bolus delay is essential for
accurate estimation of pulmonary perfusion parameters.
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