Abstract #3044
Estimation of Intra-Axonal Fraction in Spinal Cord White Matter by using Monte Carlo Simulation of Water Diffusion and High b-value Diffusion Sensitized MRI
Nabraj Sapkota 1,2 , John Rose 3 , Scott Miller 4 , Beth Bowman 4 , Lubdha Shah 4 , Erica Bisson 5 , Sook Yoon 1,6 , and Eun-Kee Jeong 1,7
1
Utah Center for Advanced Imaging Research,
University of Utah, SLC, UT, United States,
2
Department
of Physics, University of Utah, SLC, UT, United States,
3
Department
of Neurology, University of Utah, SLC, UT, United
States,
4
Department
of Radiology, University of Utah, SLC, UT, United
States,
5
Department
of Neurosurgery, University of Utah, SLC, UT, United
States,
6
Department
of Multimedia Engineering, Mokpo National Engineering,
Jeonnam, Korea,
7
Department
of Radiology, Korea University, Seoul, Korea
By using diffusion sensitized imaging (DSI), the
intra-cellular fraction (ICF) has been reported as
20-30% and is considered as a non-expected fraction.
Since extra-cellular fraction has been reported as
20-30% in the brain, it has been expected 70 80% of
ICF which is not true in white matter where myelin
occupied large fraction. Using the Monte Carlo
simulation (MCS) and DSI measurement, we estimate
intra-axonal fraction in cervical spinal cord (CSC)
white matter. The DSI measurement estimated 41% of the
contribution from intra-axonal space in pig CSC, which
fairly agrees with light microscopy result.
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