Abstract #3019
A Simplified Intravoxel Incoherent Motion Model for Diffusion Weighted Imaging in Prostate Cancer Evaluation: Comparison with Monoexponential and Biexponential Models
Qing Yuan 1 , Daniel N Costa 1,2 , Julien Sngas 3 , Yin Xi 1 , Andrea J Wiethoff 2,4 , Robert E Lenkinski 1,2 , and Ivan Pedrosa 1,2
1
Radiology, UT Southwestern Medical Center,
Dallas, TX, United States,
2
Advanced
Imaging Research Center, UT Southwestern Medical Center,
Dallas, TX, United States,
3
Philips
Research Laboratories, Hamburg, Germany,
4
Philips
Research North America, Briarcliff Manor, New York,
United States
The purpose of this study was to compare a simplified
IVIM (sIVIM) model with commonly used monoexponential
and biexponential models in diffusion characterization
of prostate cancer and noncancerous prostate tissues.
The sIVIM approach models the perfusion effect with a
Delta function at b=0 s/mm2, which allows assessment of
true tissue diffusion with fewer b-values therefore
reducing scan time. Our results demonstrated that the
sIVIM model provided ADC estimates in prostate cancer
and noncancerous prostate tissues in central gland and
peripheral zone equivalent to the biexponential model,
and it showed better correlation with tumor
aggressiveness than the monoexponential model.
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