Abstract #3006
Alterations in white matter tracts in alcohol dependence: A Tract-Based Spatial Statistics (TBSS) based DTI study
Mukesh Kumar 1 , Shilpi Modi 1 , Pawan Kumar 1 , and Subash Khushu 1
1
NMR Research Centre, Institute of Nuclear
Medicine and Allied Sciences (INMAS), New Delhi, Delhi,
India
The aim of present study was to investigate
micro-structural disruption of white matter tracts in
alcohol dependant subjects by using Tract-Based Spatial
Statistics (TBSS) of DTI measures. DTI was performed on
twenty-nine control subjects and twenty-eight alcoholic
patients. Our result showed decreased fractional
anisotropy in the anterior thalamic radiation, inferior
fronto-occipital fasciculus, superior and inferior
longitudinal fasciculus, forceps minor,corticospinal,
cingulum, uncinate fasciculus in alcohol dependant
subjects as compared to controls. These findings suggest
that the microstructural changes in these white matter
tracts may contribute to underlying dysfunction in
cognitive and behaviour as observed in them.
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