Abstract #3004
Diffusion tensor imaging of forearm nerves for early diagnosis of multifocal motor neuropathy
Wieke Haakma 1,2 , Bas Jongbloed 3 , Martijn Froeling 1 , Clemens Bos 1 , Stephan H. Goedee 3 , Michael Pedersen 4 , Ludo van der Pol 3 , Alexander Leemans 5 , and Jeroen Hendrikse 1
1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Utrecht, Netherlands,
2
Department
of Forensic Medicine & Comparative Medicine Lab, Aarhus
University, Aarhus, Central Denmark, Denmark,
3
Department
of Neurology, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands,
4
Department of
Clinical Medicine - Comparative Medicine Lab, Aarhus
University, Aarhus, Central Denmark, Denmark,
5
Image
Sciences Institute, University Medical Center Utrecht,
Utrecht, Utrecht, Netherlands
Multifocal motor neuropathy (MMN) is a rare
immune-mediated disorder that affects 1-2 person per
100.000. Due to the progressive pure motor weakness, MMN
is often confused with amyotrophic lateral sclerosis
(ALS). Diffusion tensor imaging (DTI) can be helpful in
evaluating changes of diffusion values, which may aid in
this discrimination. We studied DTI of the forearm
nerves in patients with MMN, ALS and healthy controls.
MMN patients revealed decreased fractional anisotropy
and axial diffusivity compared to healthy controls.
These preliminary results indicate a potential role of
DTI in discriminating between MMN and ALS.
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