Abstract #2996
Optimization of White Matter Fiber Tractography with Diffusional Kurtosis Imaging
G. Russell Glenn 1 , Joseph A. Helpern 2 , Ali Tabesh 3 , and Jens H. Jensen 3
1
Neurosciences & Center for Biomedical
Imaging, Medical University of South Carolina,
Charleston, SC, United States,
2
Radiology,
Neurosciences, & Center for Biomedical Imaging, Medical
Univesity of South Carolina, Charleston, SC, United
States,
3
Radiology
& Center for Biomedical Imaging, Medical Univesity of
South Carolina, Charleston, SC, United States
This study optimizes the performance of the diffusional
kurtosis imaging (DKI) approximation of the diffusion
orientation distribution function (dODF) for white
matter fiber tractography and demonstrates its
reproducibility for DKI scans with different image
acquisition protocols. It is found that a radial
weighting power of α=4 enhances the performance of the
DKI dODF while avoiding negative effects of too strong
of radial weighting. In addition, fiber tracking results
from DKI scans ranging in acquisition time from 51
minutes to 5.5 minutes demonstrated good qualitative
consistency, suggesting DKI based WM FT can be performed
on DKI datasets consistent with clinical workflows.
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