Abstract #2988
Correcting for perfusion and isotropic free diffusion in diffusion weighted imaging and DTI and CSD analysis
Martijn Froeling 1 , Peter R Luijten 1 , and Alexander Leemans 2
1
Radiology, UMC Utrecht, Utrecht,
Netherlands,
2
Image
Sciences Institute, UMC Utrecht, Utrecht, Netherlands
In this study, we have investigated the use of Intra
voxel incoherent motion (IVIM) modeling in combination
with moment nulled diffusion gradients to correct DW
imaging data for perfusion and partial volume effects
and have tested this method using diffusion tensor
imaging (DTI) and constrained spherical deconvolution
(CSD) analysis. We have shown that using Asymmetric
bipolar diffusion gradients in combination with IVIM
correction this bias can be minimized. Furthermore,
using 2nd order moment nulled DW sequences prevents
signal attenuation due to intra voxel de-phasing
originating from velocity and acceleration gradients
within a voxel resulting in more reliable IVIM fits.
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