Abstract #2884
Comparison of NOGSE and PGSE sequences for axon diameter estimation
William Perrault 1 , Tanguy Duval 1 , and Julien Cohen-Adad 1,2
1
Polytechnique de Montreal, Montreal, Quebec,
Canada,
2
Functional
Neuroimaging Unit, CRIUGM, University of Montreal,
Montreal, Quebec, Canada
Two diffusion sequences designed to measure axonal
restricted compartment were compared: Pulsed Gradient
Spin Echo (PGSE) and Non-Uniform Oscillating Gradient
Spin Echo (NOGSE). The validity of NOGSE analytical
equations was assessed using Camino. A bootstrap
procedure tested the robustness and accuracy of both
sequences at different gradient strengths: 40, 80 and
300 mT/m. Results suggest that (i) the precision of axon
diameter estimation increases with gradient strength for
both techniques and that (ii) accuracy was higher for
the NOGSE technique. The current trends pushing for
stronger gradients on clinical scanners, NOGSE technique
seems a good candidate for quantifying axon
microstructure.
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