Abstract #2872
Optimised VERDICT MRI protocol for prostate cancer characterisation
Eleftheria Panagiotaki 1 , Andrada Ianus 1 , Edward Johnston 2 , Rachel W Chan 2 , Nicola Stevens 2 , David Atkinson 2 , Shonit Punwani 2 , David J Hawkes 1 , and Daniel C Alexander 1
1
Centre for Medical Image Computing,
University College London, London, London, United
Kingdom,
2
Centre
for Medical Imaging, University College London, London,
United Kingdom
This method provides a clinically feasible imaging
protocol of 10 minutes for prostate tissue
characterization with VERDICT (Vascular Extracellular
and Restricted DIffusion for Cytometry in tumours).
Previous work used long diffusion imaging protocols in
the border of what some patients are willing to
tolerate. This work uses a computational optimization
framework with VERDICT to meet the clinical scan
duration that will enable larger clinical trials for
widespread translation. Initial results on patients
using the optimised protocol show promise for cancer
delineation via the microstructural VERDICT estimates.
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