Abstract #2847
Pushing the limits of ex-vivo diffusion MRI and tractography of the human brain
Christian Wieseotte 1,2 , Thomas Witzel 3 , Jon Polimeni 3 , Aapo Nummenmaa 3 , Bernhard Gruber 4 , Laura Schreiber 1,5 , and Lawrence Wald 3
1
Department of Radiology, Section of Medical
Physics, Johannes Gutenberg University Medical Center,
Mainz, Germany,
2
Max
Planck Graduate Center, Mainz, Germany,
3
Department
of Radiology, Massachusetts General Hospital, Athinoula
A. Martinos Center for Biomedical Imaging, Boston, MA,
United States,
4
Department
for Medical Engineering, University of Applied Sciences
Upper Austria, Linz, Austria,
5
Department
of Cellular and Molecular Imaging, Comprehensive Heart
Failure Center, Wrzburg, Germany
Because of long measurement times and the absence of
motion during image acquisition, ex-vivo DWI is capable
of achieving significantly higher spatial and angular
resolutions compared to routine in-vivo imaging. With
smaller voxel volumes however, SNR becomes the limiting
factor for increasing the spatial resolution. The
purpose of this study was to explore these limits in
ex-vivo DWI and tractography by maximizing SNR. With a
60 channel coil array optimized for post mortem human
brain specimen, a fast segmented 3D EPI acquisition and
powerful 300 mT/m gradients, an isotropic resolution of
350m was achieved.
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