Abstract #2833
The Mean Kurtosis evaluation measurements show a considerable disparity from the analytically evaluated ones for a clinically used range of b-values
Andrey Chuhutin 1 , Ahmad Raza Khan 1 , Brian Hansen 1 , and Sune Nrhj Jespersen 1,2
1
Center of Functionally Integrative
Neuroscience, Aarhus University, Aarhus, Denmark,
2
Dept.
of Physics and Astronomy, Aarhus University, Denmark
As significant sensitivity of DKI to tissue pathologies
was recently reported, this imaging modality is widely
suspected to be useful for the neural tissue structure
estimation. Being a Taylor expansion of the diffusion
signal logarithm it deemed to have a validity region. We
assessed the validity of the kurtosis evaluation versus
for a range of b-values versus an analytically
calculated ground truth based on the robust neurite
model, that proved to finely describe the properties of
the tissue. The results of the comparison show extremely
high absolute error even for moderately small b-values
both for extremely high and realistic SNR values.
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