Abstract #2803
Evidence of rotational dependency on standard DTI measurements
Arturo Cardenas-Blanco 1 , Julio Acosta-Cabronero 1 , Martin Kanowski 2 , Joern Kaufmann 2 , Claus Tempelman 2 , Stefan Teipel 3 , and Peter J Nestor 1
1
Brain plasticity and neurodegeneration,
German Center for Neurodegenerative Diseases (DZNE),
Magdeburg, Germany,
2
Department
of Neurology, Otto-von-Guericke University, Magdeburg,
Germany,
3
German
Center for Neurodegenerative Diseases (DZNE), Rostock,
Germany
DTI has become a standard research tool to probe the
structural organisation of neural tissue. Sub-optimal
acquisitions or processing methodologies can, however,
compromise the reliability of results. The aim of this
study was to challenge the assumption that enabling 30
diffusion-encoding orientations would be sufficient for
obtaining unbiased DTI measurements with standard
methods. Results showed strong effects in DTI TBSS group
analyses that were head-/FOV-positioning dependent;
suggesting, therefore, that group studies with poor
acquisition standardisation could lead to spurious
results.
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