Abstract #2786
Investigating the Extracellular Contribution to the Double-Wave-Vector Diffusion-Weighted Signal
Patricia Ulloa 1 , Viktor Wottschel 2 , and Martin A. Koch 1
1
Institute of Medical Engineering, University
of Lbeck, Lbeck, Germany,
2
Queen
Square MS Centre, UCL Institute of Neurology, University
College London, London, United Kingdom
Using two independent pairs of gradient pulses it is
possible to obtain non-invasive tissue structure
information by comparing the signal between different
diffusion gradient orientations. The
parallel-perpendicular signal difference is analyzed in
vivo and in vitro as an indicator of irregularly shaped
pores contributing to the diffusion-weighted signal. The
results suggest that the acquired signal in the
corticospinal tract contains significant contributions
from extra-axonal space, consistent with unexpectedly
large pore size estimates from earlier experiments.
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