Abstract #2713
Assessing Diastolic Function in Mouse Hearts: High-temporal resolution CINE MRI vs. Ultrasound
Thomas A Roberts 1 , Anthony N Price 2 , Anna L David 3 , Valerie Taylor 1 , Daniel J Stuckey* 1 , and Mark F Lythgoe* 1
1
Centre for Advanced Biomedical Imaging,
Division of Medicine, University College London, London,
United Kingdom,
2
Division
of Imaging Sciences and Biomedical Engineering, London,
United Kingdom,
3
Institute
for Womens Health, University College London, London,
United Kingdom
Common measures of systolic cardiac function often fail
to detect heart failure. Many patients present with
preserved ejection fraction despite underlying
pathology. Therefore, a more sensitive measure of heart
failure is required. In this study, a high-temporal
resolution (HTR-) CINE sequence (approximately one frame
every millisecond) is presented for the assessment of
diastolic function in mice. The performance of the
sequence is compared against Doppler ultrasound, which
is the established method for assessing diastolic
function. Repeatability of the HTR-CINE sequence is
shown to be comparable to ultrasound in a cohort of
nave mice. In a cohort of infarcted mice, HTR-CINE MRI
is found to be more sensitive at detecting heart failure
compared to ultrasound.
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