Abstract #2642
Ferroportin Regulates Cardiac Iron Homeostasis
Jack Miller 1,2 , Samira Lakhal-Littleton 1 , Magda Wolna 1 , Carolyn Carr 1 , Ana Santos 3 , Rebeca Diaz 3 , Daniel Biggs 3 , Ben Davies 3 , Vicky Ball 1 , Peter Robbins 1 , and Damian Tyler 1
1
Department of Physiology, Anatomy &
Genetics, University of Oxford, Oxford, United Kingdom,
2
Department
of Physics, University of Oxford, Oxford, United
Kingdom,
3
Wellcome Trust Centre for Human
Genetics, University of Oxford, Oxford, United Kingdom
Iron is vital to mamalian life. We show that the
homeostasis of iron in the heart occurs through the
protein ferroportin, which is normally only considered
in organs with a role in systemic iron homoestasis, such
as the liver. Cardiac specific ferroportin knockout mice
show severe cardiac dysfunction, as quantified by Cine
imaging, and also show a significant decrease in
myocardial T2* which correlates with an increased iron
concentration, as quantified by mass spectrometry.
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