Abstract #2612
Verification of the intra-voxel incoherent motion (IVIM) model in the porcine heart
Constantin von Deuster 1,2 , Christian T. Stoeck 1,2 , Lukas Wissmann 2 , Georg Spinner 2 , Thea Fleischmann 3,4 , Maximilian Y. Emmert 4,5 , Nikola Cesarovic 4 , and Sebastian Kozerke 1,2
1
Division of Imaging Sciences and Biomedical
Engineering, King's College London, London, United
Kingdom,
2
Institute
for Biomedical Engineering, University and ETH Zurich,
Zurich, Switzerland,
3
Institute
of Laboratory Animal Science, University of Zurich,
Zurich, Switzerland,
4
Department
of Surgical Research, University Hospital Zurich,
Zurich, Switzerland,
5
Swiss
Center of Regenerative Medicine, Zurich, Switzerland
Intra-voxel incoherent motion (IVIM) has the potential
to measure perfusion without contrast agent
administration. Its application to the heart however
remains challenging due to cardiac and respiratory
motion. In this work IVIM data was acquired with a
second order motion compensated diffusion weighted spin
echo sequence in a pig model with myocardial infarction.
The IVIM theory was validated by pre- and post-mortem
comparison in the same animal. Infarcted area identified
by a low perfusion fraction in the IVIM model agreed
with dynamic contrast-enhanced myocardial perfusion
imaging.
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