Abstract #2582
Influence of Metformin and Insulin on Myocardial Substrate Selection by 13C MRS
Cyonna Holmes 1 , Sarah Brant 1 , LaShondra Powell 1 , Michael Erik Jessen 1 , and Matthias Peltz 1
1
Cardiovascular and Thoracic Surgery,
University of Texas Southwestern Medical Center, Dallas,
Texas, United States
Coronary artery disease remains the leading case of
mortality in the United States. The diabetes drug
metformin has been shown to reduce cardiovascular
morbidity and mortality in population based studies. The
impact of metformin on myocardial metabolism has not
been well characterized. In this study, we investigated
the role of metformin on myocardial metabolism by 13C
MRS. We demonstrated that metformin reversed insulin
associated alterations in myocardial substrate
selection.
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