Abstract #2521
In Vivo Waveguide Elastography of White Matter Tracts in the Full Human Brain
Anthony Joseph Romano 1 , Jing Guo 2 , Michael Scheel 2 , Sebastian Hirsch 2 , Juergen Braun 3 , and Ingolf Sack 2
1
Physcial Acoustics, Naval Research
Laboratory, Washington, DC, United States,
2
Radiology,
Charite-Universitatsmedizin, Berlin, Germany,
3
Medical
Informatics, Charite-Universitatsmedizin, Berlin,
Germany
Waveguide Elastography combines Magnetic Resonance
Elastography, Diffusion Tensor Imaging and Orthotropic
inversions for the analysis of the anisotropic
properties of white matter. Previously, this method was
applied to the Cortico-spinal tracts of healthy human
volunteers and to patients diagnosed with Amyotrophic
Lateral Sclerosis. Here we apply this approach to the
classification of the anisotropic properties of the 12
major white matter tracts in the human brain. This
method is intended as a new modality to assess white
matter structure and health by means of the evaluation
of the anisotropic elasticity tensor of nerve fibers.
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