Abstract #2366
Cerebral Blood Flow and Metabolism in Patients with Sickle Cell Disease
Adam Bush 1 , Matthew Borzage 1 , Thomas Coates 1 , and John Wood 1
1
Children's Hospital Los Angeles USC, Los
Angeles, California, United States
In sickle cell disease (SCD) stroke is common, however
accurate quantification of basal cerebral oxygen
consumption (CMRO2) is unknown. We measured brain
volume, cerebral blood flow (CBF) and cerebral venous
saturation (SvO2) in patients with SCD using phase
contrast and TRUST MRI to address questions regarding
cerebral metabolism. We found patients with SCD to have
167% the CBF of healthy controls, a higher oxygen
delivery and a calculated CMRO2. Our study is the first
to demonstrate elevated cerebral metabolism in SCD,
mirroring increases in global resting energy expenditure
and peripheral metabolic rate described by others.
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