Abstract #2350
Scan-Rescan Variability in DCE-MRI Comparing Signal Difference and Concentration-Based Methods
Edward Ashton 1 and Jill Fredrickson 2
1
VirtualScopics, Inc., Rochester, NY, United
States,
2
Genentech,
Inc., South San Francisco, CA, United States
Dual-baseline DCE-MRI data for 43 patients drawn from
three Phase 1 clinical trials are analyzed both with and
without conversion of data from signal intensity values
to millimolar gadolinium concentration. Both model-based
(KTrans) and model-free (AUCBN) parameters are
calculated. Coefficients of variability are estimated
for both parameters using both methods, and systematic
bias between the two methods is calculated. Variability
is approximately 25% lower for both parameters using
signal intensity, primarily because conversion to
gadolinium concentration is less robust to patient
motion and other image quality issues. Absolute values
of both parameters are systematically higher using
signal difference methods.
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