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Abstract #2343

Improving the reproducibility of labeling-efficiency measurements in vivo in pseudo-continuous arterial spin labeling

Kathrin Lorenz 1,2 , Toralf Mildner 1 , Torsten Schlumm 1 , and Harald E. Mller 1,2

1 Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany, 2 Faculty of Physics and Earth Sciences, University of Leipzig, Saxony, Germany

Although pseudo-continuous arterial spin labeling (pCASL) has become the recommended choice for non-invasive perfusion measurements in the human brain, perfusion quantification is still challenging. For instance, the detected ASL signal change, and hence the estimated perfusion value, is directly proportional to the labeling efficiency lower case Greek alpha . Purpose of the current study is to investigate requirements for a high reproducibility of lower case Greek alpha measurements. It is shown that this property can be improved significantly, if both the slice position and the sampling rate of the experiment are optimized. Thereby, procedural details towards measuring lower case Greek alpha robustly in one additional pre-scan were obtained.

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