Abstract #2299
Application of Two-compartmental Pharmacokinetic Analysis with and without Vascular Term for Differentiating Benign and Malignant Spinal Tumors Measured by DCE-MRI
Ning Lang 1 , Hon J Yu 2 , Huishu Yuan 1 , and Min-Ying Su 2
1
Department of Radiology, Peking University
Third Hospital, Beijing, China,
2
Tu&Yuen
Center for Functional Onco-Imaging, University of
California, Irvine, CA, United States
DCE-MRI was performed to differentiate 4 spinal lesions
(9 myeloma, 85 metastatic cancer, 7 lymphoma, 24 benign
tuberculosis). Two-compartmental pharmacokinetic model
was used to obtain Ktrans and kep, by using the fast and
medium blood curves, with and without considering the
vascular term vp. The results showed that despite a
rapid wash-in seen in some cases, the obtained vascular
component was still low. The kep analyzed by using the
medium blood curve was the best parameter to
differentiate these 4 lesion groups. When the term vp
was considered, it had a diagnostic value, but the kep
might become less powerful.
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