Abstract #2297
A Study of MS Based on a Fusion Quantitative Analysis Model of DTI
Heather Ting Ma 1,2 , Pengfei Yang 1 , Chenfei Ye 1 , Jun Wu 3 , Xuhui Chen 3 , and Jinbo Ma 1
1
Department of Electronic and Information
Engineering, Harbin Institute of Technology Shenzhen
Graduate School, Shenzhen, Guangdong, China,
2
Radiology
Department, Johns Hopkins University, Baltimore, MD,
United States,
3
Department
of Neurology, Peking University Shenzhen Hospital,
Shenzhen, Guangdong, China
This study aimed at exploring lesion detection of
multiple sclerosis (MS) which couldnt be seen on
conventional MRI. The whole brain voxel-by-voxel DTI
analysis was performed on clinical data with a fusion
quantitative analysis model, which was based on TBSS and
VBA method with an anisotropic filter. Quantitative
comparison result for the fusion model demonstrated
statistically significant reduction of FA values in all
MS patients compared with controls. The lesions mainly
located in corpus callosum, corticospinal tract,
occipital lobe, and optic tract. The optic tract lesions
may be the direct cause for the typical clinical
symptoms of visual dysfunction in MS patients.
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