Abstract #2285
Retinal-Choroidal Blood Flow Decreases with Age: an MRI study
Oscar San Emeterio Nateras 1,2 , Joseph M Harrison 3 , Eric R. Muir 2,3 , Yi Zhang 2 , Qi Peng 2,4 , Steven Chalfin 3 , Juan E Gutierrez 5 , Daniel A Johnson 3 , Jeffrey W Kiel 3 , and Timothy Q Duong 2,3
1
Biomedical Engineering, University of Texas
at San Antonio, San Antonio, Texas, United States,
2
Research
Imaging Institute, San Antonio, Texas, United States,
3
Ophthalmology,
University of Health Science Center at San Antonio,
Texas, United States,
4
Radiology,
Albert Einstein College of Medicine, and Montefiore
Medical Center, Bronx, NY, United States,
5
Radiology,
University of Health Science Center at San Antonio,
Texas, United States
The goals of the present study were to assess the visual
fixation stability achievable with cued eye blinks for
blood-flow MRI and to test the hypothesis that
retinal-choroidal blood flow changes with age in humans.
Cued visual fixation on a target achieved adequate
stability for blood flow MRI measurement.
Retinal-choroidal blood flow negatively correlated with
age, declining 1.8ml/100ml/min per year. Such decrease
in ocular blood flow could impair delivery of oxygen and
nutrients, and removal of metabolic waste, making the
retina more susceptible to diseases.
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