Abstract #2264
Diffusion Tensor Imaging and Pathologic Correlates of Meningiomas
Sumei Wang 1 , Sungheon G Kim 2 , Maria Martinez-Lage 3 , Edward B Lee 3 , Laurie A Loevner 1 , Harish Poptani 1 , John YK Lee 4 , and Suyash Mohan 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Radiology,
New York University School of Medicine, New York, NY,
United States,
3
Pathology
and Laboratory Medicine, University of Pennsylvania,
Philadelphia, PA, United States,
4
Neurosurgery,
University of Pennsylvania, Philadelphia, PA, United
States
The purpose of this study was to correlate DTI metrics
with the histologic findings including collagen content
and Ki-67 labeling index in meningiomas. Forty-five
meningiomas underwent DTI studies. High collagen was
observed in fibroblastic meningiomas. Atypical
meningiomas showed high Ki-67. There was a significant
positive correlation between FA and collagen content
(r=0.43, p<0.05), and between CP and collagen content
(r=0.35, p<0.05). There was a significant negative
correlation between MD and Ki67 (r=0.36, p<0.05). DTI
can be helpful in predicting tumor consistency and
patient outcome.
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