Abstract #2260
IVIM-MRI Reproducibility for Functional Parametric Mapping of Treatment Response in High-Grade Glioma
Jack T Skinner 1,2 , Paul L Moots 3 , Adrienne N Dula 1,2 , and C Chad Quarles 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University Medical Center, Nashville, TN,
United States,
2
Institute
of Imaging Science, Vanderbilt University Medical
Center, Nashville, TN, United States,
3
Neurology,
Vanderbilt University Medical Center, Nashville, TN,
United States
Intravoxel incoherent motion (IVIM)-MRI has been shown
to measure brain tumor perfusion. The effect of
longitudinal treatment on IVIM estimates in glioma,
however, is unknown. To elucidate these effects,
functional IVIM mapping was performed. To implement this
technique, IVIM reproducibility was first established in
healthy subjects.
f
and
D
were
found to be reproducible (wCV < 10%) while
D*
was
less reproducible (wCV
16%).
In patients, functional maps revealed a predominate
increase in
f
with
treatment. Though a robust decrease in
D
was
observed,
ADC
remained
relatively unchanged. Functional IVIM mapping may,
therefore, help identify local regions of tumor
progression or treatment effect.
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