Abstract #2252
Metabolic activity of the invasive microenvironment of glioblastomas determines time to progression: a multimodal MR study
Stephen J. Price 1,2 , Adam MH Young 1 , William J Scotton 1 , Natalie R Boonzaier 1 , Victoria C Lupson 2 , Mary A McLean 3 , and Timothy J Larkin 1,2
1
Academic Neurosurgery Division, Dept.
Clinical Neurosciences, University of Cambridge,
Cambridge, United Kingdom,
2
Wolfson
Brain Imaging Centre, University of Cambridge,
Cambridge, United Kingdom,
3
Cancer
Research UK Cambridge Institute, University of
Cambridge, Cambridge, United Kingdom
Most patients with glioblastomas will die from disease
progressing adjacent to the resected tumor. This
invasive margin is a cardinal feature of glioblastomas
and cannot be seen on conventional imaging but can be
identified with diffusion tensor imaging. By outlining
the DTI-defined region of tumour invasion we can use
perfusion and MR spectroscopy to explore the
microenvironment. This study shows that patients with
more metabolically active invasive margins (defined as
Cho/NAA > 0.6) have a significantly longer progression
free survival. This suggests that cytotoxic therapies
have increased efficacy with more proliferative and
metabolically active invasive margins.
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