Abstract #2240
Pilocytic astrocytoma: NAA is not NAA
Benita Tamrazi 1 , Ashok Panigrahy 2 , and Stefan Bluml 1,3
1
Children's Hospital Los Angeles/USC, Los
Angeles, CA, United States,
2
Children's
Hospital of Pittsburgh, Pittsburgh, PA, United States,
3
Rudi
Schulte Research Institute, Santa Barbara, CA, United
States
MRS spectra of pediatric pilocytic astrocytoma generally
show low creatine and prominent choline. Perplexingly,
most spectra, including those acquired from large
lesions with no partial volume of surrounding tissue,
also show residual signal that appears to be consistent
with N-acetyl-aspartate. In this study we analyze the
precise chemical shift of the peak and demonstrate that
the signal is indeed not consistent with NAA. We also
show that the precise position of this peak improves the
separation of regular grade II and grade III
astrocytomas from pilocytic astrocytomas.
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