Abstract #2224
Ex-vivo brain MR morphometric-pathologic investigation in a community cohort of older adults.
Junxiao Yu 1 , Aikaterini Kotrotsou 1 , Arnold M. Evia 1 , Julie A. Schneider 2 , Sue E. Leurgans 2 , David A. Bennett 2 , and Konstantinos Arfanakis 1
1
Department of Biomedical Engineering,
Illinois Institute of Technology, Chicago, IL, United
States,
2
Rush
Alzheimer's Disease Center, Rush University Medical
Center, Chicago, IL, United States
Alzheimer's disease (AD) pathology commonly coexists
with other age-related neuropathologies in the brain of
older persons. Although brain atrophy is considered a
biomarker of AD pathology, other neuropathologies may
also lead to brain atrophy, and only a handful of
studies with a number of limitations have combined brain
MR volumetry/morphometry with measures of neuropathology
obtained after death. Thus, the relation between brain
atrophy and age-related neuropathology is not
well-established. The purpose of this investigation was
to assess the neuropathologic correlates of brain
macrostructure by combining ex-vivo MRI RAVENS maps and
pathology information on a large community cohort of
older persons.
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