Abstract #2218
Divergent episodic memory networks among APOE alleles in cognitively normal elderly
Hao Shu 1,2 , Yongmei Shi 1 , Gang Chen 2 , Zan Wang 1 , Duan Liu 1 , Chunxian Yue 1 , B.Douglas Ward 2 , Wenjun Li 2 , Zhan Xu 2 , Guangyu Chen 2 , Qihao Guo 3 , Jun Xu 4 , Shi-Jiang Li 2 , and Zhijun Zhang 1
1
Department of Neurology, Affiliated ZhongDa
Hospital, Neuropsychiatric Institute and Medical School
of Southeast University, Nanjing, Jiangsu, China,
2
Department
of Biophysics, Medical College of Wisconsin, Milwaukee,
Wisconsin, United States,
3
Department
of Neurology, Huashan Hospital, Fudan University,
Shanghai, China,
4
Department
of Neurology, Northern Jiangsu People's Hospital,
Yangzhou, Jiangsu, China
The apoliprotein E (APOE) ε4 allele is a risk factor
and the ε2 allele is a protective factor for elderly
episodic memory (EM) deterioration. However, neural
bases linking APOE alleles and EM function remain
unclear. This study voxelwisely correlated the
hippocampal functional connectivity strength and EM
score. It demonstrated the divergence of
hippocampal-related network among the three APOE alleles
in the cognitively normal elderly subjects, which may
contribute to the APOE polymorphism effects on brain
activation and associated with their different AD risks.
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