Abstract #2216
Quantitative magnetization transfer characteristics of white matter tracts correlates with DTI indices in predicting the conversion from mild cognitive impairment to Alzheimers disease
Elena Makovac 1 , Barbara Spano' 1 , Giovanni Giulietti 1 , Laura Serra 1 , Carlo Caltagirone 2,3 , Marco Bozzali 1 , and Mara Cercignani 1,4
1
Neuroimaging laboratory, IRCCS Santa Lucia
Foundation, Roma, Italy, Italy,
2
Department
of Clinical and Behavioural Neurology, IRCCS Santa Lucia
Foundation, Roma, Italy, Italy,
3
Department
of Neuroscience, University of Rome Tor Vergata, Roma,
Italy, Italy,
4
Clinical
Imaging Sciences Centre, Brighton and Sussex Medical
School, Brighton, Sussex, United Kingdom
Patients with amnestic mild cognitive impairment (aMCI)
have a higher risk of conversion to AD than healthy
elderly subjects. We used probabilistic tractography to
perform a multiparametric comparison of diffusion tensor
imaging (DTI) and quantitative magnetization transfer
(qMT) indices of the principal WM tracts involved by AD
pathology between aMCI converting to AD and those who
did not. Subtle changes in brain structure associated
were more evident in aMCI converters than MCI non
converters. RMB0 values correlated with of RDif of in
almost all tracts suggesting that the two parameters
might reflect similar properties of WM.
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