Abstract #2212
Maximizing Tissue Contrast For MRI Evaluation of Parkinsons Disease
Silvia Mangia 1 , Philip Burton 1 , Igor Nestrail 1 , Mikko Nissi 1,2 , Alejandra Sierra 3 , Karin Shmueli 4 , Michael Howell 5 , Paul Tuite 5 , and Shalom Michaeli 1
1
CMRR, University of Minnesota, Minneapolis,
Minnesota, United States,
2
University
of Oulu, Oulu, Finland,
3
A.I.Virtanen
Institute for Molecular Sciences, University of Eastern
Finland, Kuopio, Finland,
4
University
College London, London, United Kingdom,
5
Department
of Neurology, University of Minnesota, Minneapolis,
Minnesota, United States
The findings of this preliminary study support the use
of advanced MRI methods based on adiabatic T1ρ, T2ρ
RAFF4, QSM, DTI and rsfMRI to characterize the
microstructural integrity and functional connectivity of
Parkinsons disease (PD) subjects compared to healthy
controls. Ultimately these methods may prove useful as a
means to track the course of PD and potentially monitor
the response to therapies.
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