Abstract #2210
Comparative study of anatomical connectivity of prelemniscal radiations in healthy subjects and Parkinsons disease patients
Maria Guadalupe Garca-Gomar 1 , Francisco Velasco 2 , and Luis Concha 1
1
Universidad Nacional Autonoma de Mexico,
Santiago de Queretaro, Queretaro, Mexico,
2
Hospital
General de Mexico, Distrito Federal, Mexico
Synopsis: Prelemniscal radiations (Raprl) are an
exquisite neurosurgical target for treatment of tremor
and rigidity. Despite its clinical relevance nowadays it
remains unknown the anatomical connectivity of this
area. Using diffusion MRI and probabilistic tractography
we reconstructed different pathways passing trough the
Raprl in healthy subjects and Parkinsons disease
patients. We compared the number of streamlines of both
groups. Raprl tractography showed connections with motor
and premotor cortex, globus pallidus (GP), thalamus,
cerebellum and brainstem, having statistical differences
between groups in tracts associated to GP and thalamus.
Our findings provide new insights into subthalamic
anatomic connectivity useful for neurosurgical
procedures.
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