Abstract #2185
The Influence of Clinical Confounders on Imaging Biomarkers of Lesion Age in Acute Stroke
Vince I Madai 1 , Carla N Wood 1 , Ivana Galinovic 1 , Ulrike Grittner 1 , Gajanan S Revankar 1 , Steve Z Martin 1 , Olivier Zaro Weber 2 , Walter Mller-Hartmann 3 , Federico C von Samson-Himmelstjerna 1,4 , Wolf-Dieter Heiss 2 , Martin Ebinger 5 , Jochen B Fiebach 1 , and Jan Sobesky 1
1
Center for Stroke Research Berlin, Charit
Universittsmedizin Berlin, Berlin, Berlin, Germany,
2
Max
Planck Institute for Metabolism Research, Cologne,
Germany,
3
Department of Radiology,
Ludmillenstift Meppen, Meppen, Germany,
4
Fraunhofer
MEVIS, Bremen, Germany,
5
Centre
for Stroke Research Berlin, Charit Universittsmedizin
Berlin, Berlin, Germany
In acute stroke of unknown onset, the DWI-FLAIR mismatch
allows for the identification of patients presenting
within the thrombolysis time window (<4.5h). FLAIR
lesions, however, are difficult to analyze visually.
Relative-signal-intensity (rSI) biomarkers derived from
MRI sequences, namely DWI or FLAIR, constitute an
increasingly investigated observer-independent
alternative. In the present work we demonstrate that
clinical confounders (e.g. age, NIHSS) significantly
influence performance of FLAIR imaging biomarkers in
contrast to DWI biomarkers, which are independent of
this influence and offer high performance. These results
might partly explain heteregenous results for FLAIR
biomarkers in the past and support the use of DWI
biomarkers.
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