Abstract #2159
Assessment of pharmacologically induced hypothermia in a rodent model of focal cerebral ischemia using diffusion tensor imaging
Silun Wang 1 , Xiaohuan Gu 2 , Ramesh Paudyal 1 , Shan Ping Yu 2 , and Xiaodong Zhang 1,3
1
YERKES IMAGING CENTER, Emory University,
Atlanta, GA, United States,
2
Department
of Anesthesiology and Department of Neurology, Emory
University School of Medicine, GA, United States,
3
Division
of Neuropharmacology and Neurologic Diseases, Yerkes
National Primate Research Center, GA, United States
We evaluated the pharmacologically induced hypothermia
treatment response in focal cerebral ischemia induced
brain injury in a mice model using DTI. Results
indicated that significantly lower infraction volume in
the treatment group than control group. Less reduction
of ADC values were found in the hypothermia treatment
group. Our results support the use of DTI as a biomarker
to non-invasively monitor the hypothermia treatment
response in ischemia induced brain injury.
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