Abstract #2149
Monitoring Response to Neuregulin-1 in a Rat Model of Stroke Using Perfusion- and Diffusion Weighted MRI
Ramesh Paudyal 1 , Yonggang Li 2 , Silun Wang 1 , Byron D. Ford 2 , and Xiaodong Zhang 1
1
Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA,
United States,
2
Neurobiology,
Neuroscience Institute, Morehouse School of Medicine,
Atlanta, GA, United States
Neuregulin-1 (NRG-1) has shown the neuroprotective
effects in ischemic brain injury by reducing infarct
volume and protecting neurons from ischemic damage. This
study evaluates the neuroprotective effect of NRG-1 in a
rat stroke model induced by permanent middle cerebral
artery occlusion (pMCAo) using perfusion-and diffusion
weighted magnetic resonance imaging (MRI) at 3hr and 48
hr and terminal deoxynucleotidyl transferase dUTP nick
end labeling (TUNEL) and cresyl violet staining (CV) at
48 hr. Results showed that the vehicle treated group has
a significantly greater ischemic lesion volume and
mismatch region at 3hr than NRG-1 treated group. Our
finding showed that NRG-1 served as a potent
neuroprotectants in ischemic injury.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
