Abstract #2147
Combine Diffusion Tensor Imaging and RGMa Immunohistochemical Analysis to Evaluate the Crossed Cerebellar Diaschisis in Rats after Middle Cerebral Artery Occlusion
Yong Zhang 1 , Jiangliang Cheng 1 , Yanan Lin 1 , Lu Yang 1 , Shanshan Zhao 1 , and Dandan Zheng 2
1
Dept. of MRI, The First Affiliated Hospital
of Zhengzhou University, Zhengzhou, Henan, China,
2
GE
Healthcare, China, Beijing, China
The mechanism of cerebral infarction might be related to
the theory of crossed cerebral-cerebellar diaschisis
which pointed out that supratentorial focal brain damage
could cause short functional changes in its fiber linked
distant areas. In this study, we detected FA and the
RGMa protein expression in remote regions of the infarct
core in rats after MCAO at a continuous time point. The
two values were analyzed to reveal the diffusion
condition and pathological changes of the bilateral
cerebellar hemispheres and hope to give more evidences
about the relevant mechanism of crossed cerebellar
diaschisis.
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