Abstract #2126
Age-related differences in CBF, CVR, M, OEF and CMRO2 using MRI QUO2 and dual-echo pCASL
Isabelle Lajoie 1 , Kenneth S Dyson 2 , Scott Nugent 2 , Felipe D Tancredi 1,3 , and Richard D Hoge 2
1
Centre de recherche de l'IUGM, Universit de
Montral, Montreal, Quebec, Canada,
2
McConnell
Brain Imaging Centre, Montreal Neurological Institute,
McGill University, Montreal, Quebec, Canada,
3
Albert
Einstein Jewish Hospital, Brazil
It is believed that the delivery and consumption of
oxygen have an important role in the pathogenesis of
conditions such as Alzheimers Disease (AD), rising the
pertinence of developing technologies that provide such
information. We demonstrate here the potential of the
MRI method introduced in our team, dubbed QUO2, for
characterizing age-related differences in cerebral
physiology, more precisely in resting CBF, CVR, M, OEF
and CMRO2. In the next step, we will use our protocol to
evaluate the level of discrepancy between individuals
diagnosed with AD and age-matched controls.
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