Abstract #2093
Magnetic vestibular stimulation (MVS) influences fMRI resting-state fluctuations: The modulation of the default-mode network as an exemplary case
Rainer Boegle 1,2 , Thomas Stephan 1,3 , Matthias Ertl 2,3 , Stefan Glasauer 1,4 , and Marianne Dieterich 1,3
1
German Center for Vertigo and Balance
Disorders, DSGZ IFB-LMU, Munich, Bavaria, Germany,
2
Graduate
School of Systemic Neurosciences, LMU, Munich, Bavaria,
Germany,
3
Department of Neurology, LMU,
Munich, Bavaria, Germany,
4
Center
for Sensorimotor Research, LMU, Munich, Bavaria, Germany
Recently it was demonstrated that healthy subjects
inside MR machines develop a persistent nystagmus in
darkness, while patients who are lacking bilateral
peripheral vestibular function do not. We studied the
influence of this magnetic vestibular stimulation (MVS)
on fMRI resting-state fluctuations in healthy subjects,
at 1.5Tesla and at 3Tesla. We found that significant
modulation of the default mode network occurs, mainly in
areas associated with vestibular function. As proposed
for MVS, the modulation-scaling is significantly higher
than the expected BOLD signal increase due to B0 without
an additional modulation effect. We conclude that MVS
does significantly modulate fMRI resting-state networks.
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