Abstract #2040
BOLD-signal representation of incisional and inflammatory pain in rat brain after noxious electrical and noxious mechanical stimulation
Saeedeh Amirmohseni 1 , Daniel Segelcke 2 , Esther Pogatzki-Zahn 2 , and Cornelius Faber 1
1
Department of Clinical Radiology, University
Hospital Muenster, Muenster, Germany,
2
Department
of Anaesthesiology, Intensive Care and Pain Medicine,
University Hospital Muenster, Muenster, Germany
The present study investigates the BOLD-response in
pain-related brain regions in an incisional and an
inflammatory rat model during noxious electrical
stimulation (NES) and noxious mechanical stimulation
(NMS) of the injured hindpaw under the anesthesia with
medetomidine. Differences in the response to NMS and NES
were observed. Upon NMS, the response in the
inflammation group was higher as compared to both
incision and sham group. Upon NES, significantly higher
responses were observed for both pain models as compared
with the sham group. Different responses for the two
pain models were observed in S1 and RSC.
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