Abstract #2037
How specific is specific? Stimulus-evoked fMRI in rats and mice
Giovanna Diletta Ielacqua 1 , Aileen Schroeter 1 , Mark Augath 1 , Felix Schlegel 1 , and Markus Rudin 1,2
1
Institute for Biomedical Engineering, ETH
and University of Zurich, Zurich, Switzerland,
2
Institute
of Pharmacology and Toxicology, University of Zurich,
Zurich, Switzerland
Stimulus-evoked fMRI experiments in mice show widespread
hemodynamic responses even to innocuous stimulation,
indicating general arousal of the animal. Systemic
cardiovascular responses to stimuli appear to overrule
cerebral hemodynamics and mask specific stimulus-evoked
responses. Measurements in rats are less confounded by
such impact, resulting in predominantly contralateral
activation of cortical somatosensory cortical area
involved in processing of the stimulus. Here, we
characterize fMRI responses in further detail and study
three different paw stimulation paradigms (electrical,
chemical and thermal) in rats and mice. Better
understanding the interplay between specific and
systemic fMRI signal contributions should help enhancing
specificity in fMRI.
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