Abstract #2032
Etomidate: A novel anesthetic of choice for functional magnetic resonance imaging in mice
Georges Hankov* 1,2 , Marija M Petrinovic* 1 , Aileen Schroeter 2 , Andreas Bruns 1 , Markus Rudin 2,3 , Markus von Kienlin 1 , Basil Knnecke 1 , and Thomas Mueggler 1
1
Neuroscience Discovery, F. Hoffmann-La Roche
Pharmaceuticals Ltd, Basel, Basel-City, Switzerland,
2
Institute
for Biomedical Engineering, University of Zurich and
ETH, Zurich, Zurich, Switzerland,
3
Institute
of Pharmacology and Toxicology, University of Zurich,
Zurich, Switzerland
Functional MRI applied across different genetic mouse
models of neurodevelopmental disorders holds promise to
reveal pathological alteration at the neurocircuitry
level and thus to aid devising novel therapies and
biomarkers. Prerequisite is a reliable, non-terminal
anesthesia protocol that is applicable to longitudinal
studies in a broad range of mouse lines. Here, a novel
anesthesia protocol based on the injectable GABAergic
anesthetic etomidate has been established and validated
using perfusion and BOLD fMRI. Under etomidate, basal
perfusion remains in a physiological range,
cerebrovascular reserve capacity is preserved and
regions-specific perfusion- and BOLD changes are
elicited upon pharmacological and sensory stimulation,
respectively.
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