Abstract #2030
Near-Physiological Mouse fMRI of Nociception
Henning Matthias Reimann 1 , Jaroslav Marek 1 , Jan Hentschel 1 , Till Huelnhagen 1 , Andreas Pohlmann 1 , and Thoralf Niendorf 1,2
1
Berlin Ultrahigh Field Facility (B.U.F.F.),
Max Delbrueck Center for Molecular Medicine,
Berlin-Buch, Berlin, Germany,
2
Experimental
and Clinical Research Center,
Charite-Universitatsmedizin, Berlin, Germany
Chronic pain is still a major clinical issue with
limited treatment options. The combination of fMRI and
mouse genetics provides great potential for novel
targeted drug development. Still, the potential of
nociceptive mouse studies using fMRI is as yet untapped
due to methodological constraints. Here we present
enabling methodology, which allows near-physiological
nociceptive mouse fMRI studies yielding spatially
discrete BOLD effects of high magnitude for mild noxious
stimuli of 46C. This is the first report on BOLD
activation patterns or BOLD effects of this significance
and magnitude in mouse fMRI with thermostimulation.
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