Abstract #2022
Regional alterations between different anaesthesia protocols effects on the mice brain using resting-state fMRI
Tong Wu 1 , Joanes Grandjean 2 , Simone C. Bosshard 3 , Markus Rudin 2 , David Reutens 3 , and Tianzi Jiang 1,4
1
Queensland Brain Institute, The University
of Queensland, Brisbane, Queensland, Australia,
2
Institute
for Biomedical Engineering, University and ETH Zurich,
Zurich, Switzerland,
3
The Centre for Advanced
Imaging, The University of Queensland, Queensland,
Australia,
4
Brainnetome
Centre, Institute of Automation, Chinese Academy of
Sciences, Beijing, China
Anesthesia is an integral part of most resting-state
fMRI mice studies and does not influence the brain as a
whole to the same degree. This study attempts to examine
intra-regional alterations in spontaneous fMRI signals
induced by different anaesthesia protocols. Regional
homogeneity (ReHo) is a measure of the temporal
similarity of a local voxel neighborhood. We observed
that medetomidine showed increased ReHo in striatum and
decreased ReHo in the cortex and thalamus compared to
other agents. Urethane showed increased ReHo in thalamus
compared to several other agents. Global signal
regression did not introduce dramatic changes to ReHo in
this study.
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